Correlational analysis of PLIN1 with inflammation in diabetic foot ulcer wounds
Authors' conclusion
Our findings suggest that PLIN1 mediates the inflammatory damage in DFU, offering new prospects for the treatment of DFU.
Study context
- Population
- Patients with or without diabetic foot ulcers (DFUs) (foot skin, tissue and serum samples); HaCaT keratinocytes
- Comparison
- DFU vs no DFU
- Outcome
- PLIN1 expression and correlation with inflammation
Methodological detailstranscriptome sequencing, in vitro high-glucose stimulation of keratinocytes (HaCaT cells)
- Transcriptome sequencing
- In vitro high-glucose stimulation of keratinocytes (HaCaT cells)
Main finding
As reported in the abstract
- PLIN1 upregulated in tissue and serum from DFU patients
- PLIN1 positively correlated with serum leukocytes, neutrophils, monocytes, C-reactive protein and procalcitonin, and tissue IL-1β and TNF-α
- Reduced PLIN1 expression in cells led to significantly decreased iNOS, IL-1β, IL-6, IL-18 and TNF-α expression
- PLIN1 may mediate wound inflammatory damage through the NF-κB signaling pathway
Original publication
Correlational analysis of PLIN1 with inflammation in diabetic foot ulcer wounds. Diabetes Res Clin Pract. Published 6 March 2024. doi:10.
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