Association of ketone bodies with incident chronic kidney disease (CKD) and death: A UK Biobank study
Authors' conclusion
Higher KB levels were independently associated with higher risk of incident CKD and death.
Study context
- Population
- UK Biobank participants without baseline CKD with plasma β-hydroxybutyrate, acetoacetate and acetone measured at enrollment
- Participants
- 87,899 participants
- Exposure
- Higher vs lower plasma total ketone body levels
- Outcome
- Composite of:
- Incident CKD
- All-cause mortality
- Follow-up
- Median 11.9 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Adjusted hazard ratio (95 % CI)
Per 1-SD increase in log total KB7 % higher risk; multivariable Cox model
1.07(1.05–1.10)
Q4vs Q1
1.18(1.11–1.27)
- Primary outcome events
- 8,145
- Incidence rate
- 8.0/1,000 person-years
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| Incident CKD · median follow-up 11.9 years12% higher risk with Q4 | 1.12 (1.02–1.24) | |
| All-cause mortality · median follow-up 11.9 years26% higher risk with Q4 | 1.26 (1.15–1.37) | |
| 0.512Adjusted hazard ratio (log scale) |
- Incident CKD — Association consistent for incident CKD, aHR
- 1.04 (95% CI 1.01-1.07)
- All-cause mortality — Association consistent for all-cause mortality, aHR
- 1.10 (95% CI 1.07-1.13)
Original publication
Association of ketone bodies with incident CKD and death: A UK Biobank study. Diabetes Metab. Published 4 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →