Lipids & metabolic liver disease
Effects of time‐restricted eating on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease
Authors' conclusion
Among patients with NAFLD, both eTRE and lTRE induced significant reductions in intrahepatic fat and improvements in body composition, liver function, and metabolic health with similar magnitude. These findings suggest that eTRE and lTRE are comparable and feasible strategies for NAFLD management.
Study context
- Population
- Patients with nonalcoholic fatty liver disease (NAFLD); mean age 38.25 yearsall completed
- Participants
- 40 patients
- Comparison
- Early vs late time-restricted eating
- Primary endpoint
- Change in intrahepatic fat measured by MRI-derived proton density fat fraction
- Follow-up
- 8 weeks
Methodological detailsparallel-arm, open-label
- Parallel-arm
- Open-label
Primary result
As reported in the abstract
Absolute change in intrahepatic fat
Early time-restricted eating (eTRE)
−3.24%
95% CI −4.55%–-1.92%
Late time-restricted eating (lTRE)
−3.51%
95% CI −5.10%–-1.92%
Secondary outcomes
Weight, visceral fat, subcutaneous fat, liver enzymes, glucose regulatory indicators · 8 weeks
- Similar and significant reductions in both eTRE and lTRE
Original publication
Effects of time‐restricted eating on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease. Obesity (Silver Spring). Published 16 January 2024. doi:10.
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