Lipids & metabolic liver disease
Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease: The TREATY-FLD Randomized Clinical Trial
Authors' conclusion
Among adults with obesity and NAFLD, TRE did not produce additional benefits for reducing IHTG content, body fat, and metabolic risk factors compared with DCR. These findings support the importance of caloric intake restriction when adhering to a regimen of TRE for the management of NAFLD.
Study context
- Population
- Adults with obesity and nonalcoholic fatty liver disease (NAFLD), Nanfang Hospital, Guangzhou, China, 2019–2021; mean (SD) age 32.0 (9.5) years, 56% men, mean (SD) BMI 32.2 (3.3)
- Participants
- 88 adults
- Comparison
- Time-restricted eating vs daily calorie restriction
- Time-restricted eating (TRE)n = 45
- Daily calorie restriction (DCR)n = 43reference
- Primary endpoint
- Change in intrahepatic triglyceride (IHTG) content measured by MRI
- Follow-up
- 12 months
Methodological detailssingle-centre, 12-month
- Single-centre
- 12-month
Primary result
Change in IHTG content
Percentage point difference
1.0
95% CI −1.6 to 3.5
P = 0.45
Change by group
TRE
6.9%
95% CI −8.8%–-5.1%
DCR
7.9%
95% CI −9.7%–-6.2%
Between TRE and DCR
percentage point difference 1.0 (95% CI −1.6 to 3.5); P = 0.45
As reported in the abstract
Secondary outcomes
| Outcome | TRE | DCR | Percentage point difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Change in IHTG content · 6 monthsChanges comparable between groups · values are reductions in IHTG content | 8.3% (95% CI −10.0%–-6.6%) | 8.1% (95% CI −9.8%–-6.4%) | −0.2 (−2.7 to 2.2) | P = 0.86 | |
| −4−2024Difference (linear scale) |
Liver stiffness, body weight and metabolic risk factors
- Significantly and comparably reduced in both groups
Original publication
Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver Disease: The TREATY-FLD Randomized Clinical Trial. JAMA Netw Open. Published 1 March 2023. doi:10.
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