Metabolic dysfunction-associated fatty liver disease increases the risk of type 2 diabetes mellitus in young Korean adults
Main finding · Incident diabetesResult — go to the resultHazard ratio 6.148 95 % CI 6.084–6.212Authors' conclusion
MAFLD is associated with a 6.1-fold increased diabetes risk in young adults, underscoring the urgent need for early intervention to mitigate this risk.
Study context
- Population
- Korean adults aged 20–39 who underwent health examinations 2009–2012, Korean National Health Insurance Service-Health Screening Cohort; categorised also as Neither-FLD, nonalcoholic fatty liver disease (NAFLD)-only, MAFLD-only or Both-FLD
- Participants
- 6,232,656 adults
- Exposure
- MAFLD vs Non-MAFLD
- MAFLDn = 676,747
- Outcome
- Incident T2D identified through claims data
- Follow-up
- Median 9.5 years
Methodological detailsnationwide population-based, claims data
- Nationwide population-based
- Claims data
Main finding
Incident diabetes
Hazard ratio
6.148
95 % CI 6.084–6.212
MAFLDvs Non-MAFLD
HR 6.148 (95 % CI 6.084–6.212)
As reported in the abstract
- Incident diabetes cases (all participants)
- 182,291
Observational data: associations, not effects.
Further findings
- Diabetes incidence highest in FLI ≥ 60 subgroup with BMI ≥ 23 and metabolic syndrome
Original publication
Metabolic dysfunction-associated fatty liver disease increases the risk of type 2 diabetes mellitus in young Korean adults. Diabetes Res Clin Pract. Published 15 February 2024. doi:10.
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