Diabetes Duration, Cholesterol Levels, and Risk of Cardiovascular Diseases in Individuals With Type 2 Diabetes
Authors' conclusion
This population-based longitudinal study revealed that the LDL-C cutoff level for increasing the risk of CVD varied with diabetes duration and that the target LDL-C level should depend on the duration.
Study context
- Population
- Adults aged ≥ 20 years with T2D in 2015 to 2016, Korean National Health Insurance Service Cohort database
- Participants
- 2,359,243 adults
- Exposure
- Diabetes duration and low-density lipoprotein cholesterol (LDL-C) categories vs new-onset diabetes with LDL-C < 70 mg/dL
- Outcome
- MI and ischemic stroke (IS)
- Follow-up
- Mean , 3.9 years
Methodological detailslongitudinal, Cox proportional hazards model adjusted for potential confounders
- Longitudinal
- Cox proportional hazards model adjusted for potential confounders
Main finding
As reported in the abstract
Each group vs new-onset, LDL-C < 70 mg/dLHazard ratio (95% CI)
5-9 years, LDL-C 100-129 mg/dL
1.13(1.04–1.22)
5-9 years, LDL-C 130-159 mg/dL
1.28(1.17–1.39)
5-9 years, LDL-C ≥ 160 mg/dL
1.58(1.42–1.76)
≥ 10 years, LDL-C 70-99 mg/dLMI risk increased by 16%
1.16(1.08–1.25)
- Events during follow-up: Myocardial infarction (MI)
- 45 883
- Events during follow-up: Ischemic stroke (IS)
- 53 538
Observational data: associations, not effects.
Original publication
Diabetes Duration, Cholesterol Levels, and Risk of Cardiovascular Diseases in Individuals With Type 2 Diabetes. J Clin Endocrinol Metab. Published 15 February 2024. doi:10.
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