Association between low-density lipoprotein cholesterol and sudden cardiac arrest in people with diabetes mellitus
Authors' conclusion
In people with diabetes, the association between SCA and LDL-cholesterol level was U-shaped with highest and lowest LDL-cholesterol group having higher risk of SCA than others. Low LDL-cholesterol level can be a surrogate marker for increased risk of SCA in people with diabetes mellitus and this paradoxical association should be recognized and extended to clinical preventive measures.
Study context
- Population
- Patients with T2D who received general examination 2009–2012, Korean National Health Insurance Service database
- Participants
- 2,602,577 patients
- Exposure
- LDL-C categories
- Outcome
- SCA event identified with International Classification of Disease code
- Follow-up
- Mean 6.86 years
Methodological detailsKorean National Health Insurance Service database, Total follow-up 17,851,797 person-years
- Korean National Health Insurance Service database
- Total follow-up 17,851,797 person-years
Main finding
As reported in the abstract
SCA
Sudden cardiac arrest (SCA) cases identified
26,341
Observational data: associations, not effects.
Further findings
Subgroup analysis
- U-shaped association between SCA risk and LDL-C more pronounced in male, non-obese people and statin non-users
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between low-density lipoprotein cholesterol and sudden cardiac arrest in people with diabetes mellitus. Cardiovasc Diabetol. Published 20 February 2023. doi:10.
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