Cardiovascular outcomes associated with incident diabetes during statin therapy: a nationwide propensity-matched cohort study
Authors' conclusion
Diabetes that develops during statin therapy was associated with a lower risk of MACE compared with initiating statins after diabetes diagnosis and was not linked to increased risk of MACE or all-cause mortality compared with remaining diabetes-free.
Study context
- Population
- Adults in the Korean National Health Insurance Service database, 2009–2020, primary and secondary care; Study 1: 4371 incident-diabetes statin users matched 1:1 by age, sex and LDL-C; Study 2: 4191 matched 1:1source population 1,500,959
- Exposure
- Incident T2D during statin therapy vs statin initiation after prior T2D (Study 1); vs statin users remaining diabetes-free (Study 2)
- Incident T2DM on statin (Study 1)n = 4,371
- Incident T2DM on statin (Study 2)n = 4,191
- Outcome
- Major adverse cardiovascular events (MACE): composite of MI and stroke
Methodological detailstwo cohort studies, nationwide, population-based, propensity score-matched 1:1
- Two cohort studies
- Nationwide
- Population-based
- Propensity score-matched 1:1
Main finding
As reported in the abstract
MACE
Adjusted hazard ratio (95% CI)P value
Incident diabetes on statinvs Statin after T2DMStudy 1
0.607(0.458–0.805)
P = 0.0005Incident diabetes on statinvs Diabetes-free statin usersStudy 2
1.122(0.784–1.605)
P = 0.53Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| Stroke (Study 1)Incident diabetes on statinvs Statin after T2DM | 0.504 (0.357–0.711) | P < 0.001 | |
| All-cause mortality (Study 2)Incident diabetes on statinvs Diabetes-free statin users | 0.555 (0.290–1.063) | P = 0.0758 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Cardiovascular outcomes associated with incident diabetes during statin therapy: a nationwide propensity-matched cohort study. Cardiovasc Diabetol. Published 24 December 2025. doi:10.
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