Lipids & metabolic liver disease
A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial
Authors' conclusion
These results suggest that acutely prolonging the overnight fast can improve overnight substrate oxidation and that these alterations are not mediated by changes in hepatic glycogen depletion.
Study context
- Population
- Individuals with nonalcoholic fatty liver (NAFL) and healthy lean controls11 NAFL, 10 controls · Individuals with NAFL 11 · healthy lean controls 10
- Comparison
- 16-hour vs 9.5-hour overnight fast
Primary result
As reported in the abstract
Nocturnal substrate oxidation · overnight
- Extending fasting time led to lower nocturnal carbohydrate oxidation and higher fat oxidation in both groups
- 16-hour fast vs 9.5-hour fast: intervention × time, p < 0.005 for carbohydrate and fat oxidation
Further findings
| Outcome | P value |
|---|---|
| Nocturnal respiratory exchange ratio, NAFL vs controls · overnightHigher in NAFL in both arms | population p < 0.001 |
Hepatic glycogen depletion
- No changes in hepatic glycogen depletion with prolonged overnight fast in NAFL or controls
Original publication
A prolonged fast improves overnight substrate oxidation without modulating hepatic glycogen in adults with and without nonalcoholic fatty liver: A randomized crossover trial. Obesity (Silver Spring). Published 9 February 2023. doi:10.
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