Lipids & metabolic liver disease
Impact of Thyroid Function on the Prevalence and Mortality of Metabolic Dysfunction-Associated Fatty Liver Disease
Authors' conclusion
Low thyroid function is independent risk factor of MAFLD and is associated with increased risk for all-cause and cardiovascular mortality in the MAFLD population. Reevaluation of TSH reference range should be considered.
Study context
- Population
- Participants of the Third National Health and Nutrition Examination Survey (NHANES III); MAFLD diagnosed by the new definition
- Participants
- 10,666 participants
- Exposure
- Thyroid function categories by thyroid-stimulating hormone (TSH)
- Outcome
- Prevalence and mortality of MAFLD
Methodological detailsmultivariate logistic and Cox regression
- Multivariate logistic and Cox regression
Main finding
As reported in the abstract
MAFLD prevalence and all-cause and cardiovascular mortality
- Low thyroid function · MAFLD; independent association
- OR 1.27
- SCH · all-cause mortality, total population
- HR 1.23
- SCH · cardiovascular mortality, total population
- HR 1.65
- SCH · all-cause mortality, MAFLD population
- HR 1.32
- SCH · cardiovascular mortality, MAFLD population
- HR 1.99
Observational data: associations, not effects.
Original publication
Impact of Thyroid Function on the Prevalence and Mortality of Metabolic Dysfunction-Associated Fatty Liver Disease. J Clin Endocrinol Metab. Published 13 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →