Lipids & metabolic liver disease
Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease
Authors' conclusion
Lower selenium was associated with a higher BMI and increased prevalence of diabetes in females, opposite to males, and was also associated with more MI in females. Interventional studies are needed to validate this observation.
Study context
- Population
- Individuals from a community-based cohort (PREVEND) and a heart failure (HF) cohort (BIOSTAT-CHF)PREVEND N = 4288
- Participants
- 4,288 vs 1,994
- Exposure
- Lower vs higher serum selenium, by sex
- PREVENDn = 4,288
- BIOSTAT-CHFn = 1,994
- Outcome
- Sex-specific interaction between serum selenium and parameters of metabolic syndrome and HF
Methodological detailscommunity-based cohort and heart failure cohort, sex-by-selenium interaction analyses (p < 0.1)
- Community-based cohort and heart failure cohort
- Sex-by-selenium interaction analyses (p < 0.1)
Main finding
As reported in the abstract
Sex-selenium interaction with BMI, diabetes and MI · baseline
| Group | Value | BMI pinteraction | Diabetes pinteraction | Myocardial infarction (MI) pinteraction |
|---|---|---|---|---|
| PREVEND | 85.7 μg/L | < 0.001 | 0.040 | 0.021 |
| BIOSTAT-CHF | 89.1 μg/L | 0.021 | 0.024 | 0.084 |
Value
PREVEND85.7 μg/L
BIOSTAT-CHF89.1 μg/L
BMI pinteraction
PREVEND< 0.001
BIOSTAT-CHF0.021
Diabetes pinteraction
PREVEND0.040
BIOSTAT-CHF0.024
Myocardial infarction (MI) pinteraction
PREVEND0.021
BIOSTAT-CHF0.084
Observational data: associations, not effects.
Original publication
Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease. Cardiovasc Diabetol. Published 12 January 2023. doi:10.
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