Lipids & metabolic liver disease

Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction

Diabetes Obes MetabPublished Retrospective cohort study

Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.364 95% CI 1.145–1.625

Authors' conclusion

Hepatic steatosis and advanced fibrosis have a substantial prevalence among patients with AMI. Both are associated with mortality, with an incrementally higher risk when advanced fibrosis ensues. Hepatic steatosis and fibrosis could help risk stratification of AMI patients beyond conventional risk factors.

Study context

Population
Patients presenting with AMI to a tertiary hospital, 2014–2021
Participants
5,765 patients
Exposure
Hepatic steatosis vs no hepatic steatosis; advanced fibrosis vs no advanced fibrosis
Outcome
All-cause mortality
Follow-up
Median 2.7 years
Methodological detailssingle tertiary hospital
  • Single tertiary hospital

Main finding

As reported in the abstract

Adjusted hazard ratio

1.364

95% CI 1.145–1.625

P = 0.001

By group

Hepatic steatosisvs No hepatic steatosis
aHR 1.364 (95% CI 1.145–1.625); P = 0.001

Observational data: associations, not effects.

Further findings

Prevalence

Hepatic steatosis
24.8%
Advanced fibrosis among those with hepatic steatosis
41.7%

Original publication

Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction. Diabetes Obes Metab. Published 6 January 2023. doi:10.1111/dom.14950

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