Lipids & metabolic liver disease
Sex‐Stratified Associations of DXA ‐Derived Adiposity, Regional Fat Distribution and Muscle Power With Incident Hospitalised Cardiovascular Disease in Older Adults: A Prospective Cohort Study
Authors' conclusion
In this cohort of community-dwelling older adults, central adiposity was associated with higher CVD risk in men, while greater muscle power was associated with lower risk in women.
Study context
- Population
- Community-dwelling older Chinese adults; median age 72.0 years
- Participants
- 3,168 adults
- Exposure
- DXA-derived adiposity, regional fat distribution and muscle power (per 1-SD), by sex
- Menn = 1,548
- Womenn = 1,620
- Outcome
- Incident hospitalised CVD
- Follow-up
- Median 5.7 years
Methodological detailssex-stratified multivariable Cox models, Fine-Gray sensitivity analyses
- Sex-stratified multivariable Cox models
- Fine-Gray sensitivity analyses
Main finding
As reported in the abstract
Men
199
events
Women
131
events
- Participants developing cardiovascular disease (CVD)
- 330
- Men: higher adiposity (body fat %, fat mass index, waist circumference) associated with increased CVD risk, HRs per 1-SD
- 1.24-1.25
- Women only: higher muscle power associated with lower CVD risk, HRs per 1-SD
- 0.77-0.79
Observational data: associations, not effects.
Further findings
- Leg-to-total fat ratio inversely associated with cardiometabolic risk factors in both sexes (all p < 0.05)
Original publication
Sex‐Stratified Associations of DXA ‐Derived Adiposity, Regional Fat Distribution and Muscle Power With Incident Hospitalised Cardiovascular Disease in Older Adults: A Prospective Cohort Study. Diabetes Obes Metab. Published 14 September 2026. doi:10.
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