Lipids & metabolic liver disease
Short‐Term Changes in General and Central Adiposity and Subsequent Cardiometabolic Risk in Japanese Adults Undergoing Routine Health Screening
Authors' conclusion
One-year changes in BMI and WHtR were associated with subsequent cardiometabolic risk and CKM stage progression.
Study context
- Population
- Japanese employees aged 40–74 years undergoing annual health screening, 2008–2023
- Participants
- 144,394 employees
- Exposure
- 1-year changes in body mass index (BMI) and waist-to-height ratio (WHtR)
- Outcome
- Incident hypertension, dyslipidemia, hyperuricemia, diabetes, MACE, all-cause mortality and CKM stage progression
- Follow-up
- Following year
Methodological detailslongitudinal health examination data, pooled logistic regression with natural cubic splines, stratified by baseline BMI or WHtR quartiles
- Longitudinal health examination data
- Pooled logistic regression with natural cubic splines
- Stratified by baseline BMI or WHtR quartiles
Main finding
As reported in the abstract
- Increases in BMI and WHtR consistently associated with higher risks of hypertension, dyslipidemia, hyperuricemia and early cardiovascular-kidney-metabolic (CKM) stage progression across baseline body size categories
- Diabetes: increases in BMI and WHtR associated with higher risk; decreases also associated with higher risk among leaner individuals
- Associations with MACE generally U-shaped
- BMI loss associated with higher mortality odds; estimates imprecise and potentially affected by reverse causation
Observational data: associations, not effects.
Original publication
Short‐Term Changes in General and Central Adiposity and Subsequent Cardiometabolic Risk in Japanese Adults Undergoing Routine Health Screening. Diabetes Obes Metab. Published 14 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →