Lipids & metabolic liver disease
Dietary Soybean vs. Palm Oils Differ in Effects on Liver Fat in Adults With MAFLD : A 16‐Week, Double‐Masked, Randomized Controlled Trial
Authors' conclusion
There was no significant difference for the effect of PO over SO on liver fat change when controlling for baseline liver fat or weight change.
Study context
- Population
- Adults with MAFLD (mean age ≈53 y, BMI 36 kg/m²)65 completed
- Comparison
- Soybean oil vs palm oil, 30 g oils per day
- Primary endpoint
- Change of liver fat (1H-magnetic resonance spectroscopy imaging)
- Follow-up
- Week 0 to week 16
Methodological detailsdouble-masked, 2-week run-in
- Double-masked
- 2-week run-in
Primary result
As reported in the abstract
Change of liver fat · 16 weeks
- Overall, significant difference in change of liver fat between soybean oil (SO) and palm oil (PO); no longer significant after adjusting for baseline liver fat
- SO vs PO: P = 0.14
Further findings
Mediation of diet effect on liver fat change by weight change
- Direct effect of diet group on liver fat change not mediated by weight change
- P = 0.11
Within-group change of liver fat
- Liver fat tended to decrease in SO
- P = 0.11
- Liver fat tended to increase in PO
- P = 0.11
Original publication
Dietary Soybean vs. Palm Oils Differ in Effects on Liver Fat in Adults With MAFLD : A 16‐Week, Double‐Masked, Randomized Controlled Trial. Diabetes Obes Metab. Published 1 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →