Lipids & metabolic liver disease
Effects of Statins on Fat Oxidation Improvements After Aerobic Exercise Training
Authors' conclusion
Long-term statin treatment is associated with blunted exercise fat oxidation before exercise training. However, statin use does not attenuate the improvements in exercise fat oxidation (FOMAX) derived from intense aerobic exercise training. This finding should encourage statin users to exercise-train to benefit from increased fat oxidation once their fitness level improves.
Study context
- Population
- Individuals with metabolic syndrome (dyslipidemic) completing a 16-week supervised high-intensity interval training program
- Participants
- 106 individuals
- Exposure
- Long-term statin use vs statin naive, response to exercise training
- Statinn = 46
- Controln = 60reference
- Outcome
- Improvement in maximal fat oxidation (FOMAX) after exercise training
- Follow-up
- 48 hours after 16-week training
Methodological details16-week supervised high-intensity interval training
- 16-week supervised high-intensity interval training
Main finding
As reported in the abstract
| Group | Value | 95% CI |
|---|---|---|
| Statin | 0.06 ± 0.08 g·min-1 | 0.03-0.08 |
| Control | 0.05 ± 0.09 g·min-1 | 0.03-0.07 |
Value
95% CI
Observational data: associations, not effects.
Further findings
Increase in V˙O2MAX after training · larger increase with Control
P = 0.013
FOMAX before training · lower with Statin
P = 0.023
Workload at FOMAX before training · lower with Statin
P = 0.015
Workload at FOMAX after training · lower workload with Statin
28% · P = 0.048
V˙O2-workload slope and fat oxidation across workloads · after training
- V˙O2-workload slope decreased after training in both groups, with reductions in respiratory exchange ratio-workload slope
- both P < .001
- Fat oxidation increased at all workloads after training regardless of statin use
Original publication
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