Lipids & metabolic liver disease
Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training
Authors' conclusion
Impaired glycaemic regulation in MASLD is characterized by greater hepatic lipid saturation; however, this composition is not altered by 6 weeks of moderate-intensity exercise training.
Study context
- Population
- Men with MASLD (liver PDFF ≥5.56%)40 men in Part A
- Participants
- 14 / 26 / 13 / 13
- Comparison
- IGR vs normal glycaemic regulation (NGR); exercise training vs non-exercise control in IGR
- NGRn = 14reference
- IGRn = 26
- EXn = 13
- Control (CON)n = 13reference
- Primary endpoint
- Hepatic saturated lipid index (SI), by proton magnetic resonance spectroscopy
Methodological detailsPart A cross-sectional, Part B randomized controlled trial, 6-week intervention
- Part A cross-sectional
- Part B randomized controlled trial
- 6-week intervention
Primary result
As reported in the abstract
Hepatic SI and UI (Part A)
- Hepatic SI higher and UI lower in IGR vs NGR
- IGR vs NGR: P = 0.038
Secondary outcomes
| Outcome | P value |
|---|---|
| Hepatic lipid composition and liver PDFF (Part B) · 6 weeksEX vs CON · unchanged | P ≥ 0.257 |
| FPG and VO2 peak (Part B) · 6 weeksEX vs CON · FPG reduced, VO2 peak increased | P ≤ 0.030 |
Hepatic lipid composition and liver PDFF (Part B) · 6 weeks
- Hepatic lipid composition and liver PDFF unchanged after EX vs CON
Associations of hepatic lipid profile (Part A)
- Lipid profile associated with higher HbA1c, fasting plasma glucose (FPG), homeostatic model assessment of insulin resistance (HOMA-IR) and CK18 M65 (rs)
- ≥0.320
ΔVO2 peak vs Δhepatic lipid indices (Part B)
- ΔVO2 peak vs Δhepatic SI (r)
- −0.433
- ΔVO2 peak vs Δhepatic UI and PUI (r)
- ≥ 0.433
Original publication
Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training. Diabetes Obes Metab. Published 8 July 2024. doi:10.
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