Glycaemic control metrics and metabolic dysfunction–associated steatotic liver disease in children and adolescents with type 1 diabetes
Authors' conclusion
MASLD is a common condition in children and adolescents with T1D. The mean HbA1c values from diabetes onset, TAR and LDL cholesterol levels were the independent predictors of MASLD.
Study context
- Population
- Children and adolescents with T1D (115 girls, mean age 16.2 ± 3.2 years)
- Participants
- 244 children
- Exposure
- With vs without MASLD
- Outcome
- Prevalence of MASLD and its association with glycaemic control metrics
Main finding
As reported in the abstract
Prevalence of MASLD
Prevalence of MASLD
27.5%
Observational data: associations, not effects.
Further findings
Independent predictors of MASLD (logistic regression)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Mean HbA1c from diabetes onset | 1.703 (1.040–2.787) | P = 0.034 | |
| TAR | 1.028 (1.009–1.047) | P = 0.006 | |
| Plasma LDL-C | 1.045 (1.013–1.078) | P = 0.004 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Characteristics with vs without MASLD
- Blood pressure, total cholesterol, LDL-C, non-HDL cholesterol, HbA1c and time above range (TAR) significantly higher with MASLD than without
Original publication
Glycaemic control metrics and metabolic dysfunction–associated steatotic liver disease in children and adolescents with type 1 diabetes. Diabetes Obes Metab. Published 30 September 2024. doi:10.
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