Altered oxidant and antioxidant levels are associated with vascular stiffness and diabetic kidney disease in type 1 diabetes after exposure to acute and chronic hyperglycemia
Authors' conclusion
Biomarkers of oxidative stress are associated with vascular stiffness and DKD following acute and chronic hyperglycemic exposure and may provide added value to HbA1c in understanding disease pathology, predicting risk and assessing the status of secondary complications of type 1 diabetes.
Study context
- Population
- Individuals with T1D (FinnDiane study) with varying degrees of DKD (normal, moderate or severe albuminuria), and non-diabetic controls118 in chronic study
- Participants
- 22 / 13 / 60 / 58
- Comparison
- T1D vs non-diabetic controls; high vs low HbA1c and DKD severity
- T1Dn = 22
- Non-diabetic controlsn = 13reference
- Low HbA1cn = 60reference
- High HbA1cn = 58
- Outcome
- Oxidant and antioxidant levels and vascular stiffness
Methodological detailsacute hyperglycaemic clamp study, chronic hyperglycaemia study
- Acute hyperglycaemic clamp study
- Chronic hyperglycaemia study
Main finding
As reported in the abstract
Association of high malondialdehyde (MDA) with AIx (combined analysis)
r2 = 0.611
p = 0.05
Association of delta reactive oxygen metabolites (ROMs) with delta AIx (combined analysis)
r2 = 0.955
p = 0.014
Original publication
Altered oxidant and antioxidant levels are associated with vascular stiffness and diabetic kidney disease in type 1 diabetes after exposure to acute and chronic hyperglycemia. Cardiovasc Diabetol. Published 28 September 2024. doi:10.
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