Ambulatory blood pressure monitoring and vascular complications in patients with type 1 diabetes mellitus – Systematic review and meta-analysis of observational studies
Authors' conclusion
Small mean differences in blood pressure parameters, as measured by ABPM, between people with T1DM are associated with a lower incidence or risk of progression of nephropathy and retinopathy.
Study context
- Population
- Office normotensive people with T1D undergoing Ambulatory Blood Pressure Monitoring (ABPM); aged 25.8 ± 6.2 years, 57.5 % men, diabetes duration 11.8 ± 5.3 years, HbA1c 8.5 % ± 1.6 %
- Participants
- 635 people7 studies
- Comparison
- ABPM parameters in people with vs without vascular complications
- Outcome
- Vascular outcomes:
- Albuminuria
- Onset
- Progression of retinopathy
- Follow-up
- Mean 4.2 years
Methodological detailscohort studies, random effect model, 364 articles found, 49 duplicates
- Cohort studies
- Random effect model
- 364 articles found, 49 duplicates
Pooled result
As reported in the abstract
Vascular complications (albuminuria, retinopathy onset or progression) by ABPM parameters
- Lower night systolic BP associated with lower incidence of albuminuria
- MD - 4.37 mmHg (p = 0.0009)
- Lower night diastolic BP associated with lower incidence of albuminuria
- MD - 3.97 mmHg (p < 0.0001)
- Lower night diastolic BP in those with no beginning or progression of retinopathy
- MD - 3.62 mmHg (p = 0.042)
- Lower diurnal diastolic BP in those with no beginning or progression of retinopathy
- MD - 2.69 mmHg (p = 0.0138)
- Lower 24-hour diastolic BP in those with no beginning or progression of retinopathy
- MD - 3.65 mmHg (p = 0.037)
Original publication
Ambulatory blood pressure monitoring and vascular complications in patients with type 1 diabetes mellitus – Systematic review and meta-analysis of observational studies. Diabetes Res Clin Pract. Published 27 September 2024. doi:10.
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