Presentation and characteristics of children with screen-detected type 1 diabetes: learnings from the ELSA general population pediatric screening study
Authors' conclusion
There are three main learnings from this case series. First, T1D identified through screening is at an earlier stage of its natural history and requires personalized insulin regimens with lower total daily insulin doses. Second, single autoantibody seropositivity can rapidly progress to stage 3. Finally, insulin requirement can manifest at any stage of the T1D screening pathway, and therefore early education around symptom recognition is essential for families participating in screening programs.
Study context
- Population
- Children diagnosed with stage 3 T1D through the ELSA general population pediatric screening study
- Participants
- 14 children
- Outcome
- Presentation of screen-detected T1D
Methodological detailsgeneral population screening
- General population screening
Main finding
As reported in the abstract
- Median presenting HbA1c
- 6.6% (49 mmol/mol)
- Insulin requirements
- <0.5 units/kg/day
- Identified at stage 3 by ELSA
- 4 children
- Progressed within 4 months of ELSA completion, incl. 2 single seropositive
- 4 children
- Developed stage 3 T1D prior to ELSA completion
- 6 children
Observational data: associations, not effects.
Safety
DKA prior to confirmed antibody status
- Children with DKA
- 14%, n=2/14
Original publication
Presentation and characteristics of children with screen-detected type 1 diabetes: learnings from the ELSA general population pediatric screening study. BMJ Open Diabetes Res Care. Published 26 September 2024. doi:10.
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