Integrative oral and gut microbiome profiling highlights microbial correlates of complications in type 1 diabetes: a cross-sectional analysis
Authors' conclusion
Distinct oral and gut microbiome features are associated with chronic vascular complications in T1D. These findings highlight the potential of microbiome-targeted strategies for understanding and preventing T1D-related complications.
Study context
- Population
- Long-standing T1D (duration ≥ 10 years) and healthy controls
- Participants
- 75 vs 43
- Exposure
- T1D with vs without vascular complications; T1D vs healthy controls
- T1Dn = 75
- Healthy controlsn = 43reference
- Outcome
- Oral and gut microbiome features associated with vascular complications
Methodological detailsshotgun metagenomic sequencing
- Shotgun metagenomic sequencing
Main finding
As reported in the abstract
Core set of gut and oral microbial species specifically associated with vascular complications
26 gut and 8 oral species
Observational data: associations, not effects.
Original publication
Integrative oral and gut microbiome profiling highlights microbial correlates of complications in type 1 diabetes: a cross-sectional analysis. Cardiovasc Diabetol. Published 24 December 2025. doi:10.
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