Effects of gut microbiome on type 1 diabetes susceptibility and complications: A large‐scale bidirectional Mendelian randomization and external validation study
Authors' conclusion
Our findings supported the potential causal effect of gut microbiota on the susceptibility and complications of T1D.
Study context
- Population
- Patients with T1D; external validation with gutMEGA datasets and the National Clinical Research Center for Metabolic Diseases
- Participants
- 60 vs 30
- Comparison
- Gut microbiome taxa vs T1D susceptibility and complications
- T1Dn = 60
- Controlsn = 30reference
- Outcome
- Effect of gut microbiome on T1D susceptibility (MR)
Methodological detailstwo-sample Mendelian randomization (MR), reverse MR, mediation and multivariable MR
- Two-sample MR
- Reverse MR
- Mediation and multivariable MR
Performance
As reported in the abstract
- Veillonellaceae can potentially reduce T1D susceptibility (discovery and validation MR phases)
- E. coprostanoligenes group significantly associated with lower risk of renal, neurological and ophthalmic complications in T1D
Further findings
| Outcome | T1D | Controls |
|---|---|---|
| Average relative abundance of Veillonellaceae, gutMEGA dataset | 0.66% | 1.09% |
| Median relative abundance of Veillonellaceae, external validation | median 1.10% (CI 0.50%–1.80%) | — not stated in the abstract |
— not stated in the abstract
Median relative abundance of Veillonellaceae, external validation
- Lower in T1D than controls
HDL cholesterol measures and T1D complications
- High cholesterol in small HDL and cholesteryl esters in HDL associated with reduced risk of T1D renal and ophthalmic complications
- Mediation and multivariable MR: E. coprostanoligenes group is the most dominant factor influencing T1D complications
Original publication
Effects of gut microbiome on type 1 diabetes susceptibility and complications: A large‐scale bidirectional Mendelian randomization and external validation study. Diabetes Obes Metab. Published 16 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →