The relationship between FGF23 and body composition according to albuminuria stage in type 1 diabetes
Authors' conclusion
In type 1 diabetes, the relationship between FGF23 and body composition is dependent on albuminuria stages.
Study context
- Population
- Adults with T1D from the Finnish Diabetic Nephropathy Study, and controls; body composition by DXA, serum FGF23 by ELISA306 with T1D + 36 controls
- Participants
- 229 / 38 / 39 / 36
- Exposure
- FGF23 and body composition across albuminuria stages in T1D vs controls
- T1Dnormon = 229reference
- T1Dmicron = 38
- T1Dmacron = 39
- Controlsn = 36
- Outcome
- Associations between serum FGF23 and body composition (linear regression), by albuminuria stage
Main finding
As reported in the abstract
Association of FGF23 with body composition, adjusted for potential confounders
- T1Dmicro: FGF23 positively associated with % total fat, visceral fat and android fat; negatively associated with lean tissue
- T1Dnormo, T1Dmacro and controls: FGF23 not associated with body composition
- Adjusted for potential confounders
Observational data: associations, not effects.
Further findings
Characteristics vs T1Dnormo
- More advanced kidney disease: older, longer DM duration, higher serum hsCRP and higher FGF23
- FGF23 comparable between T1Dnormo and controls
Original publication
The relationship between FGF23 and body composition according to albuminuria stage in type 1 diabetes. Diabetes Res Clin Pract. Published 12 March 2023. doi:10.
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