Risk factors for pre-clinical atherosclerosis in adolescents with type 1 diabetes
Authors' conclusion
Oxidative stress, male gender, insulin dose, diabetes duration and longitudinal lipids and blood pressure, contributed to the variance of early vascular damage in young patients with T1D.
Study context
- Population
- Children/adolescents with T1D (130 girls, age 9.1–23.0 years)130 girls
- Participants
- 267 participants
- Outcome
- Associations of traditional risk factors, oxidative stress, oxLDL and glycemic variability with early vascular damage (z-cIMT, z-PWV, Lp-PLA2)
Methodological detailsgeneral linear models
- General linear models
Main finding
As reported in the abstract
Determinants of early vascular damage (general linear models)
- z-cIMT: male gender
- B = 0.491, η2 = 0.029, p = 0.005
- z-cIMT: cSBP
- B = 0.023, η2 = 0.026, p = 0.008
- z-cIMT: oxLDL
- B = 0.022, η2 = 0.022, p = 0.014
- z-PWV: diabetes duration
- B = 0.054, η2 = 0.024, p = 0.016
- z-PWV: daily insulin dose
- B = 0.52, η2 = 0.018, p = 0.045
- z-PWV: longitudinal z-SBP
- B = 0.18, η2 = 0.018, p = 0.045
- z-PWV: dROMs
- B = 0.003, η2 = 0.037, p = 0.004
- Lp-PLA2: age
- B = 0.221, η2 = 0.079, p = 3*10-6
- Lp-PLA2: oxLDL
- B = 0.081, η2 = 0.050, p = 2*10-4
- Lp-PLA2: longitudinal LDL-C
- B = 0.031, η2 = 0.043, p = 0.001
- Lp-PLA2: male gender
- B = −1.62, η2 = 0.10, p = 1.3*107
Observational data: associations, not effects.
Original publication
Risk factors for pre-clinical atherosclerosis in adolescents with type 1 diabetes. Diabetes Res Clin Pract. Published 9 March 2023. doi:10.
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