Effect of Diactive-1 mHealth-Supported Progressive Resistance Training on Insulin Requirements, Glycemic Stability, and Muscular Strength in Children and Adolescents With Type 1 Diabetes: A Parallel-Group Randomized Controlled Trial
Primary result · Daily insulin doseResult — go to the resultMD −0.17 units/kg 95% CI −0.26 to −0.07Authors' conclusion
Diactive-1 appears to be a safe and feasible adjunct to standard care in children and adolescents with type 1 diabetes. Its resistance training component effectively reduced insulin requirements and improved muscular strength, without increasing the risk of adverse glycemic events.
Study context
- Population
- Children and adolescents aged 8–18 years with T1D (girls 48%; HbA1c 7.6% [60.4 mmol/mol])4 withdrew
- Participants
- 62 children
- Comparison
- Diactive-1 mHealth-supported progressive resistance training vs usual care
- Diactive-1n = 30
- Usual caren = 32reference
- Primary endpoint
- Daily insulin dose
- Follow-up
- 24 weeks
Methodological detailsparallel-group, 24-week
- Parallel-group
- 24-week
Primary result
As reported in the abstract
MD
−0.17 units/kg
95% CI −0.26 to −0.07
Diactive-1vs Usual care
MD −0.17 units/kg (95% CI −0.26 to −0.07)
- Daily insulin dose reduction within Diactive-1
- −0.10 (MD, units/kg; 95% CI −0.18 to −0.01)
Further findings
- Handgrip strength increased
- 2.90 (MD, kg; 95% CI 1.57-4.22)
- One-repetition maximum strength increased
- 1.34 (MD; 95% CI 0.21-2.46)
- Muscular power increased
- 0.97 (MD; 95% CI 0.01-1.93)
Safety
Glycemic risk index and hypoglycemic events
- No adverse effects observed on the glycemic risk index or the incidence of hypoglycemic events
Withdrawal
- Participants withdrew from the study
- 4 (6.5%)
Original publication
Effect of Diactive-1 mHealth-Supported Progressive Resistance Training on Insulin Requirements, Glycemic Stability, and Muscular Strength in Children and Adolescents With Type 1 Diabetes: A Parallel-Group Randomized Controlled Trial. Diabetes Care. Published 13 August 2025. doi:10.
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