Trends in Total Daily Dose and Variability of Insulin Requirements in Newly Diagnosed Children and Adolescents with Type 1 Diabetes over 48 Months
Authors' conclusion
During the first 48 months after diagnosis of T1D, insulin requirements in children and adolescents more than double with hybrid closed-loop insulin delivery.
Study context
- Population
- Children and adolescents aged 10–16 years with newly diagnosed T1D
Methodological detailsopen-label, multicentre, parallel, closed-loop arm only
- Open-label
- Multicentre
- Parallel
- Closed-loop arm only
Primary result
As reported in the abstract
Total daily insulin dose (TDD) · 0-3 months to 42-48 months after diagnosis
Total daily dose (TDD) at 0-3 months after diagnosis, mean ± SD
27.2 ± 16.1 units/d
TDD at 42-48 months, mean ± SD
65.7 ± 24.9 units/d
Further findings
Proportion of total daily insulin delivered as basal insulin · over 48 months
- Basal proportion rose from 41% to 61%
Day-to-day variability of insulin requirements (CV) · 0-3 months; over 48 months
- CV at 0-3 months (high)
- 23.3 ± 0.9%
- Variability remained stable over 48 months
Sex-based differences in insulin requirements
- No clinically relevant sex-based differences
Original publication
Trends in Total Daily Dose and Variability of Insulin Requirements in Newly Diagnosed Children and Adolescents with Type 1 Diabetes over 48 Months. Diabetes Technol Ther. Published 13 August 2025. doi:10.
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