The automated correction index (ACI), a novel report-derived metric correlated to glucose control and variability in patients with type 1 diabetes on advanced hybrid closed loop therapy
Authors' conclusion
The ACI could represent a useful and easy-to-assess metric for AHCL-treated individuals with T1D. In our cohort an ACI < 30 % was associated to better glucose control and variability.
Study context
- Population
- Adult and pediatric patients with T1D using different advanced hybrid closed loop (AHCL) systems87 adult, 37 pediatric
- Participants
- 124 participants
- Exposure
- ACI <30% vs ACI ≥30%
- Outcome
- Correlation of AHCL parameters (TDD, total daily basal (TDBa), TDBo, ACI) with HbA1c and sensor-derived metrics
Methodological detailsretrospective
- Retrospective
Main finding
As reported in the abstract
Association of ACI with HbA1c, TAR and TIR
- ACI the only AHCL-derived parameter directly associated with HbA1c
- p = 0.03
- ACI directly associated with TAR 180-250 mg/dL (10-13.9 mmol/L)
- p < 0.01
- ACI inversely correlated with TIR 70-180 mg/dL (3.9-10 mmol/L)
- p < 0.01
Observational data: associations, not effects.
Further findings
HbA1c by ACI category · reduced HbA1c with ACI < 30 %
P = 0.02
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| TIR > 70 % | 3.18 (1.19–8.46) | P = 0.02 | |
| CV < 36 % | 2.86 (1.07–8.27) | P = 0.03 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
The automated correction index (ACI), a novel report-derived metric correlated to glucose control and variability in patients with type 1 diabetes on advanced hybrid closed loop therapy. Diabetes Res Clin Pract. Published 10 April 2025. doi:10.
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