Clinical effectiveness of different advanced hybrid closed-loop systems on time in tight range in adults with type 1 diabetes: A multicenter real-world study
Authors' conclusion
AHCL systems are useful for achieving TITR >50%, with no differences between treatment groups. However, this study has detected differences in some aspects of glycemic control between the devices used which could have clinical implications.
Study context
- Population
- Adults ≥18 yrs with T1D treated with the same AHCL device for ≥3 months, Spain; female 66.8%, mean age 42.8 ± 12.8 yrs, T1D duration 23.5 ± 11.8 yrs
- Participants
- 189 adults
- Exposure
- MM780G vs Control-IQ (Control-IQ) vs CamAPS AHCL systems
- Outcome
- Differences in time in tight range (TITR) between the three AHCL systems
Methodological detailsmulticenter, observational, real-world, consecutive recruitment
- Multicenter
- Observational
- Real-world
- Consecutive recruitment
Main finding
As reported in the abstract
TITR
- Overall time in tight range (TITR) (mean ± SD)
- 51.7 ± 11.6%
- No between-group differences in TITR
- P = 0.154
Observational data: associations, not effects.
Further findings
Nocturnal TITR — CamAPS vs MM780G · higher with CamAPS
P = 0.029
| Outcome | P value |
|---|---|
| Nocturnal TITRCamAPS vs Control-IQ · higher with CamAPS | P = 0.029 |
HbA1c
- HbA1c higher with MM780G vs both Control-IQ and CamAPS (6.9 ± 0.7% vs. 6.5 ± 0.6%)
- P = 0.003
Time on AHCL automatization (all)
- Time on AHCL automatization
- 94.6 ± 7.6%
Safety
Time below range level 1 — CamAPS vs MM780G · higher with CamAPS
P < 0.001
Time below range level 2 — CamAPS vs MM780G · higher with CamAPS
P < 0.001
| Outcome | P value |
|---|---|
| Time below range level 1CamAPS vs Control-IQ · higher with CamAPS | P < 0.001 |
| Time below range level 2CamAPS vs Control-IQ · higher with CamAPS | P < 0.001 |
Original publication
Clinical effectiveness of different advanced hybrid closed-loop systems on time in tight range in adults with type 1 diabetes: A multicenter real-world study. Diabetes Metab. Published 2 April 2026. doi:10.
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