Evaluation of time in tight range and the glycaemia risk index in adults with type 1 diabetes using an advanced hybrid closed loop system: A 1‐year real‐world assessment
Authors' conclusion
The results highlight the sustained effectiveness of Tandem t:slim X2 with Control-IQ in improving glycaemic outcomes over 1 year and support the use of this technology for the management of T1D.
Study context
- Population
- Adults with T1D who transitioned to the Tandem t:slim X2 with Control-IQ advanced hybrid closed-loop (AHCL) system
- Participants
- 56 adults
- Exposure
- Before vs after initiation of Tandem t:slim X2 with Control-IQ AHCL
- Outcome
- Change in time in tight range (TiTR; 70-140 mg/dL)
- Follow-up
- 1 year
Methodological detailssingle-centre, real-world
- Single-centre
- Real-world
Main finding
As reported in the abstract
Mean TiTR (70-140 mg/dL)
P = 0.059
Observational data: associations, not effects.
Secondary outcomes
Mean
| Outcome | Baseline | 1 year | P value |
|---|---|---|---|
| Glycaemia risk index (GRI) · 1 yearDecline | 41.03 (SD 25.48) | 28.55 (SD 16.27) | P = 0.008 |
Other continuous glucose monitoring (CGM) metrics, mean sensor glucose, glucose management indicator (GMI), HbA1c, insulin daily dose
- CGM metrics incl. time in range and time above range showed consistent improvements
- Mean sensor glucose, GMI and HbA1c decreased significantly over time
- After an initial increase, insulin daily dose remained stable throughout 12 months
Original publication
Evaluation of time in tight range and the glycaemia risk index in adults with type 1 diabetes using an advanced hybrid closed loop system: A 1‐year real‐world assessment. Diabetes Obes Metab. Published 15 July 2024. doi:10.
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