Glycemic Risk Index in a Cohort of Patients with Type 1 Diabetes Mellitus Stratified by the Coefficient of Variation: A Real-Life Study
Authors' conclusion
In this study, the factors independently associated with metabolic control according to GRI are modified by glycemic variability.
Study context
- Population
- Adults with T1D using intermittently scanned continuous glucose monitoring (isCGM) with adherence ≥70%; mean age 44.6 years (SD 13.7), 57.7% male, age at diabetes mellitus (DM) onset 24.5 years (SD 14.3), DM duration 20.6 years (SD 12.3)
- Participants
- 447 adults
- Exposure
- Coefficient of variation (CV) >36% vs CV ≤36%
- Outcome
- GRI with its hypoglycemia (CHypo) and hyperglycemia (CHyper) components, by CV
Methodological detailsreal-life
- Real-life
Main finding
GRI
Difference
18.8 %
P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Difference (%) | P value |
|---|---|---|
| CHypoSD 0.3 | 2.9 | P < 0.001 |
| CHyperSD 1.4 | 6.3 | P < 0.001 |
Classical glucometric parameters
- Differences in all classical glucometric parameters except TAR level 1
Factors independently associated with Glycemic Risk Index (GRI), CV >36% (multivariate linear regression)
- Time in range (TIR) β
- −1.49 (95% CI −1.63 to −1.37; P < 0.001)
- Glucose management indicator (GMI) β
- −7.22 (95% CI −9.53 to −4.91; P < 0.001)
- CV β
- 0.85 (95% CI 0.69 to 1.02; P < 0.001)
Factors independently associated with GRI, CV ≤36% (multivariate linear regression)
- Age β
- 0.15 (95% CI 0.03 to 0.28; P = 0.019)
- Age of onset β
- −0.15 (95% CI −0.28 to −0.02; P = 0.023)
- TIR β
- −1.35 (95% CI −1.46 to −1.23; P < 0.001)
- GMI β
- −6.67 (95% CI −9.18 to −4.15; P < 0.001)
- CV β
- 0.33 (95% CI 0.11 to 0.56; P = 0.004)
Original publication
Glycemic Risk Index in a Cohort of Patients with Type 1 Diabetes Mellitus Stratified by the Coefficient of Variation: A Real-Life Study. Diabetes Technol Ther. Published 10 July 2024. doi:10.
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