Obesity

Intermittently Scanned Continuous Glucose Monitoring Enhances Weight Loss and Adherence in Women with Obesity: A Randomized Controlled Trial

Diabetes Technol TherPublished Randomised controlled trial

Authors' conclusion

Integrating isCGM into lifestyle interventions enhances adherence and supports clinically significant improvements in body composition and glycemic control among women with obesity.

Study context

Population
Women with overweight or obesity (BMI > 25 kg/m²); both groups had supervised exercise (3 sessions/week) and identical dietary counseling
Participants
35 women
Comparison
Intermittently scanned continuous glucose monitoring (isCGM) at baseline, mid-intervention and study end vs isCGM only at baseline and end, alongside supervised exercise and dietary counseling
  • Interventionn = 17
  • Controln = 18reference
Primary endpoint
Changes in body weight and BMI
Follow-up
12 weeks

Primary result

As reported in the abstract

Change in body weight

Intervention

−5.5

± 2.3 · kg

Control

−0.2

± 1.8 · kg

P < 0.001

Secondary outcomes

Clinically meaningful weight loss (≥3% BMI and body fat reduction)

OutcomeInterventionControlP value
Change in BMI (primary outcome) · 12 weeks−1.9 ± 0.6 kg/m²−0.1 ± 0.4 kg/m²P < 0.001
Waist-to-height ratio, body fat, visceral fat, muscle mass and dietary adherence
P < 0.05

Waist-to-height ratio, body fat, visceral fat, muscle mass and dietary adherence

Significantly greater reductions in waist-to-height ratio, body fat and visceral fat, increased muscle mass and improved dietary adherence with intervention vs controls

TIR

TIR improved modestly in the intervention group
P = 0.03

Original publication

Intermittently Scanned Continuous Glucose Monitoring Enhances Weight Loss and Adherence in Women with Obesity: A Randomized Controlled Trial. Diabetes Technol Ther. Published 17 February 2026. doi:10.1177/15209156261423952

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