Efficacy of Oral Antiobesity Medications With Versus Without Adjunct Behavioral Weight Management Treatment
Authors' conclusion
Combining oral AOMs with behavioral treatment via telemedicine resulted in significantly greater weight loss than medications alone, supporting the recommendation to pair AOMs with behavioral treatment.
Study context
- Population
- Patients eligible for bupropion and naltrexone from a telehealth weight management clinic (WeightWatchers Clinic); 94.1% female, mean age 43.9 years (SD 10.7), mean BMI 37.0 kg/m² (SD 6.3)
- Participants
- 101 patients
- Comparison
- Bupropion and naltrexone with vs without behavioral treatment
- Bupropion and naltrexone with behavioral treatmentn = 51
- Bupropion and naltrexonen = 50reference
- Primary endpoint
- Change in weight (kg)
- Follow-up
- 12 weeks
Methodological detailstwo-arm, 12-week, telehealth, Remote measurements of body weight, behavioral and psychosocial measures at baseline and week 12
- Two-arm
- 12-week
- Telehealth
- Remote measurements of body weight, behavioral and psychosocial measures at baseline and week 12
Primary result
As reported in the abstract
12-week change in weight (kg)
Absolute weight change, with vs without behavioral treatment: mean difference (significantly more weight lost with behavioral treatment)
−1.8 kg
p = 0.03
Further findings
Percent weight change · 12 weeks
- Percent weight change, with vs without behavioral treatment: mean difference (significantly more weight lost with behavioral treatment)
- −1.6%, p = 0.04
Original publication
Efficacy of Oral Antiobesity Medications With Versus Without Adjunct Behavioral Weight Management Treatment. Obesity (Silver Spring). Published 17 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →