Clinical Guidelines for the Diagnosis and Management of Generalized and Partial Lipodystrophies: A Position Statement Endorsed by the Hellenic Endocrine Society
Methodological detailstargeted literature review, expert consensus, 2 multidisciplinary panels, Literature search of PubMed, MEDLINE, Scopus and Google Scholar from inception through October 2024, Expert consensus from 2 multidisciplinary panels convened by the Hellenic Endocrine Society in 2024-2025
- Targeted literature review
- Expert consensus
- 2 multidisciplinary panels
- Literature search of PubMed, MEDLINE, Scopus and Google Scholar from inception through October 2024
- Expert consensus from 2 multidisciplinary panels convened by the Hellenic Endocrine Society in 2024-2025
Recommendations
As issued by the authors
Early recognition relies on careful assessment of fat distribution, metabolic abnormalities, and selected use of imaging and genetic testing
Multidisciplinary management: lifestyle interventions, pharmacologic treatment of diabetes, dyslipidemia and liver disease, and metreleptin in eligible patients
Adjunctive GLP-1 RA and SGLT2i may offer additional metabolic benefit in selected cases
Psychosocial support is essential due to the high burden of psychological distress and stigma
Original publication
Clinical Guidelines for the Diagnosis and Management of Generalized and Partial Lipodystrophies: A Position Statement Endorsed by the Hellenic Endocrine Society. Endocr Pract. Published 17 February 2026. doi:10.
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