Assessing the feasibility of time in tight range (TITR) targets with advanced hybrid closed loop (AHCL) use in children and adolescents: A single‐centre real‐world study
Authors' conclusion
Most children and adolescents on AHCL achieved the 50% target for TITR whereas more than half achieved the >60% target. A target of >50% for TITR seems realistic in children with T1D using AHCL.
Study context
- Population
- Children and adolescents with T1D using AHCL (Minimed-780G); 2128-day CGM data
- Participants
- 56 children
- Exposure
- Autocorrection rate <30% vs ≥30%; TITR >60% vs not
- Outcome
- Attainability of the TITR (3.9-7.7 mmol/L) target with AHCL
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Attainment of TITR targets
TITR >50%
87%
TITR >60%
52%
Observational data: associations, not effects.
Further findings
TIR by autocorrection rate · significantly higher with Group 1
p: 0.008
TITR by autocorrection rate · significantly higher with Group 1
p: 0.002
Time in Range (TIR) and TITR, nighttime vs daytime
- TIR nighttime vs daytime
- 87.5 ± 9.5% vs. 78.8 ± 8%, p < 0.001
- TITR nighttime vs daytime
- 68.2 ± 13.5% vs. 57.5 ± 8.8%, p < 0.001
Safety
Hypoglycaemia (time below range (TBR)), TITR >60% (n: 29) vs without (n: 27)
- TBR 3-3.9 mmol/L, TITR >60% vs without: no significant difference
- 0.3% vs. 2.1%, p: 0.084
- TBR < 3 mmol/L, TITR >60% vs without: no significant difference
- 0.47% vs. 0.3%, p: 0.298
Original publication
Assessing the feasibility of time in tight range (TITR) targets with advanced hybrid closed loop (AHCL) use in children and adolescents: A single‐centre real‐world study. Diabet Med. Published 26 April 2024. doi:10.
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