A register‐based study describing time trends in risk factor control and serious hypoglycaemia together with the effects of starting continuous glucose monitoring in people with type 1 diabetes in Norway
Authors' conclusion
Between 2012 and 2020, we found marked improvements in glycaemic control and a considerable decrease in the proportion of individuals reporting serious hypoglycaemia. The proportion of individuals using CGM increased substantially and individuals that had started using CGM by 2020 showed greater improvement in glycaemic control and less serious hypoglycaemia.
Study context
- Population
- People with T1D in Norway, Norwegian Diabetes Register for Adults (NDR-A)cohort of 2057
- Exposure
- 2020 vs 2012; started continuous glucose monitoring (CGM) 2013–2020 vs not started CGM
- 2012n = 5,746reference
- 2020n = 18,984
- Outcome
- Mean HbA1c (cross-sectional surveys)
- Follow-up
- 2012 to 2020
Methodological detailstwo cross-sectional surveys (2012, 2020), real-world setting, Norwegian Diabetes Register for Adults (NDR-A)
- Two cross-sectional surveys (2012, 2020)
- Real-world setting
- Norwegian Diabetes Register for Adults (NDR-A)
Main finding
As reported in the abstract
2012
66
mean · 99% CI 65–66 · mmol/mol (8.2%)
2020
61
mean · 99% CI 61–61 · mmol/mol (7.7%)
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | 2012 | 2020 | Started CGM | Not started CGM | Greater improvement (mmol/mol (0.3%)) | P value |
|---|---|---|---|---|---|---|
| Proportion reporting serious hypoglycaemia (cross-sectional surveys) · 2012 to 20202020 vs 2012 · decreased | 16.9% | 6.2% | — not stated in the abstract | — not stated in the abstract | P < 0.0001 | |
| Mean LDL-C (cross-sectional surveys) · 2012 to 20202020 vs 2012 · decreased · mmol/l | 2.80 (99% CI 2.78–2.83) | 2.63 (99% CI 2.61–2.65) | — not stated in the abstract | — not stated in the abstract | P < 0.0001 | |
| Improvement in mean HbA1c (CGM cohort) · 2012 to 2020Started CGM vs Not started CGM · greater improvement with Started CGM | 3 | |||||
| Change in serious hypoglycaemia (CGM cohort) · 2012 to 2020 | — not stated in the abstract | — not stated in the abstract | −12.3% | −6.2% |
— not stated in the abstract
Mean blood pressure (cross-sectional surveys) · 2012 to 2020
- Mean blood pressure increased slightly
Change in serious hypoglycaemia (CGM cohort) · 2012 to 2020
- Greater reduction in serious hypoglycaemia with Started CGM
Original publication
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