Severe hypoglycaemia is associated with increased risk of adverse cardiovascular complications in adults with type 1 diabetes: risk mitigation using intermittently scanned continuous glucose monitoring
Main finding · Hospitalisations for CVD complicationsResult — go to the resultRelative rate 2.06 95% CI 1.48–2.85Authors' conclusion
In adults with type 1 diabetes, SHE is associated with an increased risk of hospitalisation for adverse CVD complications. This risk is significantly reduced in isCGM users compared with BGM control participants.
Study context
- Population
- Adults with T1D, Swedish National Diabetes Register; up to 2 years of follow-up1,313 with index severe hypoglycaemia events (SHE)
- Participants
- 14,829 adults
- Exposure
- Prior SHE vs no SHE; Intermittently scanned continuous glucose monitoring (isCGM) vs blood glucose monitoring (BGM) after SHE
- SHEn = 1,313
- isCGMn = 970
- BGMn = 343reference
- Outcome
- Hospitalisation for CVD complications
- Follow-up
- Up to 2 years
Methodological detailscomparative, Swedish National Diabetes Register and National Patient Register
- Comparative
- Swedish National Diabetes Register and National Patient Register
Main finding
Hospitalisations for CVD complications
Relative rate
2.06
95% CI 1.48–2.85
As reported in the abstract
Observational data: associations, not effects.
Further findings
Per 100 person-years
| Outcome | isCGM | BGM | Relative rate (95% CI) | P value |
|---|---|---|---|---|
| Hospitalisations for post-SHE CVD complications, isCGM vs BGM78% relative reduction; adjusted for confounders | 5.40 (CI 4.59–6.31) | 14.23 (CI 11.95–16.82) | 0.22 (0.11–0.43) | P < 0.001 |
Original publication
Severe hypoglycaemia is associated with increased risk of adverse cardiovascular complications in adults with type 1 diabetes: risk mitigation using intermittently scanned continuous glucose monitoring. Diabetologia. Published 24 April 2025. doi:10.
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