Time in tight glucose range in adolescents and young adults with diabetes during Ramadan intermittent fasting: Data from real-world users on different treatment strategies
Authors' conclusion
At the end of Ramadan, TITR was decreased in patients with T1DM except those using AHCL who had similar levels to non-insulin-treated T2DM patients. Advanced technology has the potential for achieving tight glycemic targets, along with a reduction in CoV, without increasing hypoglycemic risk compared with other insulin treatment modalities.
Study context
- Population
- Adolescents and young adults with diabetes during Ramadan intermittent fasting
- Exposure
- Time in tight range (TITR) across treatment strategies (MDI + intermittently scanned CGM (isCGM), sensor augmented pump (SAP), advanced hybrid closed loop (AHCL) in T1D) vs non-insulin-treated T2D during Ramadan fasting
- T2DMn = 276
- T1DMn = 426
- Outcome
- Attainability of TITR (70-140 mg/dL) target
- Follow-up
- End of Ramadan
Methodological detailsreal-world
- Real-world
Main finding
As reported in the abstract
T1DM
42.3
mean · ± 6.6 · %
T2DM
63.5
mean · ± 4.0 · %
AHCL
62.3
± 11.6 · %
SAP
37.7
± 5.7 · %
MDI + isCGM
23.6
± 5.9 · %
T1DM vs T2DM: P < 0.001 · Between AHCL and MDI + isCGM: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| CoV in AHCL vs other T1DM participants · RamadanLower CoV with AHCL | P < 0.001 |
Safety
TBR <70 mg/dL in AHCL, during vs before Ramadan
P = 0.061
TBR <54 mg/dL in AHCL, during vs before Ramadan
P = 0.561
Original publication
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