A Multicenter Prospective Evaluation of the Benefits of Two Advanced Hybrid Closed-Loop Systems in Glucose Control and Patient-Reported Outcomes in a Real-world Setting
An erratum to this article was published (Diabetes Care, 1 Dec 2024 ↗)
Authors' conclusion
The two AHCL provide significant improvement in glucose control and satisfaction, with no superiority of one AHCL over the other.
Study context
- Population
- AHCL-naïve adolescents and adults with T1D, 14 centers; age 39.9 ± 11.4 years [16–72], 64% female, diabetes duration 21.6 ± 11.9 years
- Participants
- 150 adolescents
- Exposure
- MM780G with SmartGuard vs Tandem t:slimX2 with Control-IQ
- MM780Gn = 75
- Control-IQn = 75
- Outcome
- Between-group difference in change in TIR 70-180 mg/dL from beginning to end of follow-up
- Follow-up
- 3 months
Methodological detailsmulticenter, real-world
- Multicenter
- Real-world
Main finding
As reported in the abstract
TIR 70-180 mg/dL · baseline to 3 months
- TIR increased overall from 61.53 ± 14.01% to 76.17 ± 9.48% (P < 0.001)
- MM780G vs Control-IQ: P = 0.591
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HbA1c · baseline to 3 months | P = 0.819 between groups |
| Diabetes-related distressGreater improvement with Control-IQ | P = 0.012 |
HbA1c · baseline to 3 months
- HbA1c decreased by 0.56% (95% CI 0.44%, 0.68%) (P < 0.001)
- MM780G: from 7.43 ± 1.07% to 6.88 ± 0.60% (P < 0.001 to baseline)
- Control-IQ: from 7.14 ± 0.70% to 6.56 ± 0.53% (P < 0.001 to baseline)
Fear of hypoglycemia and quality of life
- No superiority of one AHCL over the other
Sleep quality (PSQI) · baseline to 3 months
- PSQI improved from 6.94 ± 4.06 to 6.06 ± 4.05, without differences between systems
- P = 0.004
Experience with AHCL (INSPIRE)
- Experience exceeded the expectations
Original publication
A Multicenter Prospective Evaluation of the Benefits of Two Advanced Hybrid Closed-Loop Systems in Glucose Control and Patient-Reported Outcomes in a Real-world Setting. Diabetes Care. Published 10 November 2023. doi:10.
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