Stroke incidence increases with diabetic retinopathy severity and macular edema in type 1 diabetes
Authors' conclusion
Stroke incidence increases with the severity of diabetic retinopathy independently of comorbid conditions, including diabetic kidney disease.
Study context
- Population
- Adult FinnDiane Study participants with T1D (age 38.7 ± 11.8 years, 51.7% men, 31.5% with DKD) with baseline DR severity data
- Participants
- 1,268 participants
- Exposure
- Non-proliferative and proliferative retinopathy vs no-very mild retinopathy
- Outcome
- First stroke
- Follow-up
- Median 18.0 (14.1-19.3) years
Methodological detailsobservational follow-up, Cox models adjusted for clinical confounders incl. DKD
- Observational follow-up
- Cox models adjusted for clinical confounders incl. DKD
Main finding
As reported in the abstract
Stroke · median 18.0 (14.1-19.3) years
Each group vs no-very mildAdjusted hazard ratio (95% CI)
Non-proliferative
1.79(1.02–3.15)
Proliferative
1.69(1.02–2.82)
- Strokes occurred (96 ischemic, 34 hemorrhagic)
- 130
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| Ischemic strokeNon-proliferativevs No-very mild | 1.68 (0.91–3.10) | |
| Ischemic strokeProliferativevs No-very mild | 1.35 (0.77–2.36) | |
| Hemorrhagic strokeNon-proliferativevs No-very mild | 2.84 (0.66–12.28) | |
| Hemorrhagic strokeProliferativevs No-very mild | 4.31 (1.16–16.10) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Clinically significant macular edema (CSME) and stroke
- CSME did not increase HR for any stroke type after adjustment (data not shown)
Original publication
Stroke incidence increases with diabetic retinopathy severity and macular edema in type 1 diabetes. Cardiovasc Diabetol. Published 25 April 2024. doi:10.
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