Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes
Authors' conclusion
Our results, for the first time, comprehensively indicate that the rs9939609 FTO polymorphism could be considered a genetic marker for increased susceptibility to T1D complications and comorbidities as well as suggests importance of FTO-mediated pathways in their etiology.
Study context
- Population
- Patients with T1D
- Comparison
- FTO rs9939609 genotypes
- Outcome
- Associations of FTO rs9939609 with T1D, its complications and comorbidities
Main finding
As reported in the abstract
- rs9939609 FTO polymorphism does not predispose to T1D
- AA genotype associated with increased risk of overweight and obesity, retinopathy, hypertension, dyslipidemia and celiac disease
- AT genotype associated with decreased risk of retinopathy and celiac disease
- TT genotype associated with decreased risk of dyslipidemia
Further findings
Inflammatory markers and lipid profile
- FTO rs9939609 polymorphism affects inflammatory status and lipid profile in T1D
Original publication
Associations of the obesity gene FTO variant with complications and comorbidities in patients with type 1 diabetes. Diabetes Res Clin Pract. Published 24 April 2024. doi:10.
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