Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes
Authors' conclusion
The LL genotype of the HMOX1 GTn repeat and the AA genotype of -413A/T SNP were associated with ischemic cardiac complications and all-cause mortality in men, but not in women. Thus, the HMOX1 genotype may influence the development of cardiovascular complications in individuals with T1D in a sex-dependent manner.
Study context
- Population
- Individuals with T1D in the Finnish Diabetic Nephropathy Study (FinnDiane)GTn genotyped n = 3990
- Participants
- 4,278 individuals
- Comparison
- HMOX1 GTn repeat LL vs SS/SL genotype
- Outcome
- Vascular complications (ischemic cardiac events) and all-cause mortality
Main finding
As reported in the abstract
Ischemic cardiac events, men
P = 0.001
- LL genotype associated with all-cause mortality in men
- P = 0.031
Further findings
Ischemic cardiac events, all individuals
P = 0.006
Ischemic cardiac events, women
P = 0.657
| Outcome | P value |
|---|---|
| Serum HO-1 concentration by sexMen vs Women · higher in men | P < 0.001 |
- Serum HO-1 concentration by sex: Men 3.12 ± 1.23 ng/ml
- Serum HO-1 concentration by sex: Women 2.64 ± 1.04 ng/ml
- Serum HO-1 concentration by sex: serum HO-1 measured in n = 861
Ischemic cardiac events, men, −413A/T SNP AA genotype
- Men with AA genotype had ischemic cardiac events more frequently (21.0% vs. 17.4%)
- P = 0.044
- No differences for women or men and women together
+99G/C variant and CV complications
- No differences between genotypes regarding CV complications
Serum HO-1 by genotype
- No difference in HO-1 serum concentrations between genotypes (GTn, −413A/T or +99G/C)
Serum HO-1 concentration by sex
- In women, higher HO-1 associated with CVD and need for antihypertensive and lipid-lowering medications
Original publication
Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes. Cardiovasc Diabetol. Published 18 August 2025. doi:10.
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