Type 1 diabetes, its complications, and non-ischemic cardiomyopathy: a mendelian randomization study of European ancestry
Authors' conclusion
The study demonstrates a causal relationship between T1D, its complications, and NICM. Additionally, monokine induced by gamma interferon may act as a potential mediator in the pathogenesis of T1D-NICM.
Study context
- Population
- Genome-wide association study summary data for T1D (two datasets); T1D with complications and non-ischemic cardiomyopathy (NICM) from the Finnish database
- Comparison
- Genetically predicted T1D and T1D with complications vs NICM risk
- Outcome
- Non-ischemic cardiomyopathy (NICM)
Methodological detailstwo-sample Mendelian randomization (MR), multivariable MR, mediation MR, European ancestry
- Two-sample MR
- Multivariable MR
- Mediation MR
- European ancestry
Main finding
As reported in the abstract
NICM
Odds ratio (95% CI)P value
T1D
1.02(1.01–1.04)
P = 1.17e-04T1D with complications
1.03(1.01–1.05)
P = 3.15e-3Further findings
NICM, T1D adjusted for BMI and hypertension (multivariable MR)
| OR (95% CI) | P value | ||
|---|---|---|---|
| T1D | 1.02 (1.01–1.04) | P = 1.35e-4 | |
| 0.512Odds ratio (log scale) |
Mediation by monokine induced by gamma interferon in T1D-NICM
| OR (95% CI) | P value | ||
|---|---|---|---|
| Mediation effect (monokine induced by gamma interferon) | 1.005 (1.001–1.01) | P = 4.9e-2 | |
| 0.512Odds ratio (log scale) |
Original publication
Type 1 diabetes, its complications, and non-ischemic cardiomyopathy: a mendelian randomization study of European ancestry. Cardiovasc Diabetol. Published 13 January 2024. doi:10.
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