Genetic Causality between Type 1 Diabetes and Arrhythmia Identified by a Two-sample Mendelian Randomization Study
Authors' conclusion
Our MR analysis revealed a causal association between T1D and the development of arrhythmia, indicating that patients with T1D had a higher risk of arrhythmia.
Study context
- Population
- Genome-wide association studies of T1D and arrhythmia28 SNPs
- Comparison
- Genetically predicted T1D and arrhythmia
- Outcome
- Causal effect of T1D on arrhythmia (inverse variance-weighted method)
Methodological detailsgenome-wide association study summary statistics, 28 SNPs as instrumental variables
- Genome-wide association study summary statistics
- 28 SNPs as instrumental variables
Main finding
As reported in the abstract
Arrhythmia (IVW)
IVW OR (95% CI 0.97-1.00), P = 0.008
0.98
Further findings
Arrhythmia (weighted median)
- Weighted median OR (95% CI 0.96 - 0.99), P = 0.009
- 0.98
Arrhythmia (weighted mode)
- Weighted mode OR (95% CI 0.96-0.99), P = 0.018
- 0.98
Horizontal pleiotropy and heterogeneity
- MR-Egger: no horizontal pleiotropy, P
- 0.649
- Q-test: no heterogeneity (IVW), P
- 0.653
Original publication
Genetic Causality between Type 1 Diabetes and Arrhythmia Identified by a Two-sample Mendelian Randomization Study. Diabetes Res Clin Pract. Published 31 May 2024. doi:10.
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