Prevalence and associations of impaired awareness of hypoglycemia in a pediatric type 1 diabetes population – The Norwegian Childhood Diabetes Registry
Authors' conclusion
IAH is prevalent in pediatric diabetes and more likely reported in young children. IAH is associated with severe hypoglycemia and fear of hypoglycemia, but good metabolic control seems achievable without increased risk of IAH.
Study context
- Population
- Children and adolescents aged 2–19 years (median 13.3) with T1D ≥6 months (median 4.6 years), Norwegian Childhood Diabetes Registry; 53% males; parents responded for children <9 years51% participation · parents responded for children <9 years 235
- Participants
- 1,329 children
- Outcome
- Prevalence of impaired awareness of hypoglycemia (IAH), self-assessed with the validated Clarke questionnaire
Methodological detailsnationwide, population-based, registry-based
- Nationwide
- Population-based
- Registry-based
Main finding
As reported in the abstract
Prevalence of IAH
Overall prevalence of impaired awareness of hypoglycemia (IAH)
22 %
IAH prevalence in preschoolers
53 %
IAH prevalence in adolescents aged ≥16 years
12 %
Observational data: associations, not effects.
Further findings
Associations with IAH (adjusted OR; 95% CI)
| aOR (95 % CI) | ||
|---|---|---|
| Severe hypoglycemia episodes in preceding year | 6.0 (3.04–11.8) | |
| DKA in preceding year | 3.45 (1.37–8.68) | |
| Female sex | 1.41 (1.05–1.90) | |
| 0.050.21520Adjusted odds ratio (log scale) |
| Outcome | aOR (95 % CI) | |
|---|---|---|
| Associations with IAH (adjusted OR; 95% CI)Fear of hypoglycemia, highest quartilevs Lowest quartile | 2.27 (1.51–3.40) | |
| Associations with IAH (adjusted OR; 95% CI)HbA1c ≥ 8.5 % (69 mmol/mol)vs HbA1c 7.5-8.4 % (58-68 mmol/mol) | 1.48 (1.01–2.18) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Associations with IAH (adjusted OR; 95% CI)
- Not associated with disease duration, insulin pump or CGM use, or HbA1c < 7.5 % (58 mmol/mol)
Original publication
Prevalence and associations of impaired awareness of hypoglycemia in a pediatric type 1 diabetes population – The Norwegian Childhood Diabetes Registry. Diabetes Res Clin Pract. Published 13 January 2024. doi:10.
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