Hybrid Closed Loop in Adults With Type 1 Diabetes and Severely Impaired Hypoglycemia Awareness
Authors' conclusion
Six months of HCL use in high-risk adults with severe IAH increased glucose TIR and improved GRI without increased hypoglycemia, and partially restored counter-regulatory responses.
Study context
- Population
- Adults with T1D and impaired awareness of hypoglycaemia, Edmonton HYPO scores ≥1047completed
- Participants
- 9 adults
- Comparison
- Hybrid closed-loop (HCL) vs standard therapy without continuous glucose monitoring (CGM)
- HCLn = 5
- Controln = 4reference
- Primary endpoint
- Percentage CGM time-in-range (TIR) (70-180 mg/dL)
- Follow-up
- 23 to 26 weeks post-randomization
Primary result
As reported in the abstract
TIR · 23 to 26 weeks
P = 0.014
Secondary outcomes
Hypoglycaemia episode duration · shorter with HCL
P < 0.001
| Outcome | HCL | Control | P value |
|---|---|---|---|
| Time <70 mg/dLDid not differ | 3.8% (IQR 2.7–3.9) | 6.5% (IQR 4.3–8.6) | P = 0.14 |
| Glycemia risk index (post hoc) · 26 weeksLower with HCL · post hoc analysis | 38.1 (IQR 30.0–39.2) | 70.8 (IQR 58.5–72.4) | P = 0.014 |
| Dopamine response to hypoglycaemia · 6 monthsGreater with HCL | 24.0 (IQR 12.3–27.6) | −18.5 (IQR −36.5–-4.8) | P = 0.014 |
| GH response to hypoglycaemia · 6 monthsGreater with HCL | 6.3 (IQR 4.6–16.8) | 0.5 (IQR −0.8–3.0) | P = 0.050 |
Original publication
Hybrid Closed Loop in Adults With Type 1 Diabetes and Severely Impaired Hypoglycemia Awareness. J Diabetes Sci Technol. Published 13 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →