Hybrid Closed-Loop Disconnection Reduces the Risk of Hypoglycemia in Active Children and Adolescents with Type 1 Diabetes: A Randomized Controlled Pilot Study
Authors' conclusion
Temporary HCL disconnection for exercise significantly reduces hypoglycemia risk without compromising glucose control.
Study context
- Population
- Children and adolescents with T1D using Medtronic MiniMed 780 G and continuous glucose monitoring (CGM) at a 7-day holiday camp (1–2 exercise sessions/day); median age 11 (10–11) years, diabetes duration 1.6 (0.7–6.0) years, HbA1c 6.4 (6.05–7.3)%8 and 7 analysed
- Participants
- 20 children
- Comparison
- Hybrid closed-loop (HCL) suspended and disconnected vs kept connected in auto-mode for physical activity
- Disconnectedn = 7
- Connectedn = 8reference
Methodological detailsprospective, pilot, 7-day holiday camp
- Prospective
- Pilot
- 7-day holiday camp
Primary result
As reported in the abstract
TBR <70 mg/dL [3.9 mmol/L] · during camp
HCL exercise disconnection resulted in lower TBR <70 mg/dL (%point difference ± spread as printed)
−2.91 ± 1.3%point
P = 0.0250
Further findings
TIR 70-180 mg/dL [3.9-10.0 mmol/L] · during camp
- No difference in TIR with HCL exercise disconnection (%point, ± spread as printed)
- +0.3 ± 4.8%point, P = 0.1677
Original publication
Hybrid Closed-Loop Disconnection Reduces the Risk of Hypoglycemia in Active Children and Adolescents with Type 1 Diabetes: A Randomized Controlled Pilot Study. Diabetes Technol Ther. Published 23 January 2026. doi:10.
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