Insulin Bolus Patterns in Newly Diagnosed Youth With Type 1 Diabetes Using a Hybrid Closed-Loop Insulin Delivery System
Authors' conclusion
The decline in the proportion of total daily insulin delivered for as bolus is likely attributable to a combination of missed boluses and under-bolusing, while the closed-loop algorithm compensates for the missed or insufficient carbohydrate-related insulin delivery by increasing basal insulin delivery.
Study context
- Population
- Youth with newly diagnosed T1D using a hybrid closed-loop system
- Primary endpoint
- Proportion of total daily insulin delivered as boluses (decline over time)
- Follow-up
- 48 months
Methodological detailsopen-label, multicentre, parallel
- Open-label
- Multicentre
- Parallel
Primary result
As reported in the abstract
- Decreased from 58% to 34%
Further findings
Carbohydrates entered per day · over 48 months
- Decreasing trend in median (IQR) from 236 (204, 253) g to 184 (127, 232) g
Carbohydrate-related boluses per day · over 48 months
- Decreasing trend in median (IQR) from 5.5 (4.6, 6.5) to 3.7 (2.9, 5.2)
Daily carbohydrate-related bolus insulin · over 48 months
- Mean ± SD increased from 15.1 ± 6.6 to 22.0 ± 9.0 units/d
Insulin delivered per 10 g of carbohydrate · over 48 months
- More than doubled from 0.6 (0.5, 0.8) units to 1.3 (0.9, 1.5) units
Postprandial change in glucose (peak glucose 30–180 min post carbohydrate-related bolus minus glucose at bolus) · over 48 months
- Changed from 49 (45, 54) to 59 (53, 66) mg/dL
Original publication
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