Clinical outcomes of adults with type 1 diabetes and comorbid depression and/or anxiety disorders using hybrid closed‐loop: A retrospective study from a multidisciplinary tertiary centre
Authors' conclusion
HCL users demonstrated improved HbA1c and TIR, compared with non-HCL users. These real-world data support safe use of HCL in people with type 1 diabetes and depression/anxiety in a multidisciplinary setting. Qualitative studies and prospective trials are required to further evaluate the impact of HCL on biomedical and mental health outcomes.
Study context
- Population
- Adults with T1D and comorbid depression and/or anxiety disorders, King's College Hospital diabetes centre, Oct 2023–Jan 2025; 163 female/63 male; median age 38 years; 196 depression, 119 anxietyof 1827 adults with T1D
- Participants
- 226 adults
- Exposure
- Hybrid closed-loop (HCL) users vs non-HCL users
- HCL usersn = 108
- Non-HCL usersn = 118reference
- Outcome
- HbA1c and TIR
- Follow-up
- Last
Methodological detailssingle-centre, real-world
- Single-centre
- Real-world
Main finding
As reported in the abstract
last follow-up
| Group | Value | Haemoglobin A1c (HbA1c) % | TIR |
|---|---|---|---|
| HCL users | 60.0 (IQR 53.0–66.0) mmol/mol | 7.6% (7.0-8.2) | 63.5 (55.8-75.0) |
| Non-HCL users | 73.0 (IQR 58.5–85.5) mmol/mol | 8.8% (7.5-10.0) | 42.0 (23.0-55.3) |
Value
HCL users60.0 (IQR 53.0–66.0) mmol/mol
Non-HCL users73.0 (IQR 58.5–85.5) mmol/mol
Haemoglobin A1c (HbA1c) %
HCL users7.6% (7.0-8.2)
Non-HCL users8.8% (7.5-10.0)
TIR
HCL users63.5 (55.8-75.0)
Non-HCL users42.0 (23.0-55.3)
- HCL users vs Non-HCL users: P < 0.001 — lower HbA1c with HCL users
- HCL users vs Non-HCL users: P < 0.001 — higher TIR with HCL users
Observational data: associations, not effects.
Further findings
Glycaemia post- vs pre-HCL initiation
P < 0.001
HbA1c % Post-HCL 7.6% (7.0-8.2) · Pre-HCL 8.3% (7.5-9.3)
TIR Post-HCL 63.5 (55.8-75.0) · Pre-HCL 39.0 (28.0-55.8)
| Outcome | P value |
|---|---|
| Glycaemia post- vs pre-HCL initiation | P < 0.001 |
- Diabetes distress scale (DDS2) scores · lower post-HCL
- P = 0.004
- DDS2 scores · no difference
- P = 0.230
Safety
| Outcome | P value |
|---|---|
| Acute complicationsHCL users vs Non-HCL users · did not vary | P = 0.380 |
| Acute complicationsHCL users vs Non-HCL users · fewer HCL users experienced ketoacidosis | P < 0.001 |
Original publication
Clinical outcomes of adults with type 1 diabetes and comorbid depression and/or anxiety disorders using hybrid closed‐loop: A retrospective study from a multidisciplinary tertiary centre. Diabetes Obes Metab. Published 20 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →