Effect of Automated Insulin Delivery Using Hybrid Closed Loops in the Preconception, Peripartum and Postnatal Periods for Women With Type 1 Diabetes
Authors' conclusion
When started preconception or in pregnancy, HCL significantly reduces HbA1c at three months and improves TIR by 15% to 20% within one week.
Study context
- Population
- Women with T1D using hybrid closed loop (HCL) in the preconception, peripartum and postnatal periods, single centre, UK
- Participants
- 46 / 21 / 25
- Exposure
- Before vs after HCL initiation
- Preconceptionn = 46
- Pregnancyn = 21
- Postnataln = 25
- Outcome
- Effect of HCL use upon HbA1c and CGM metrics, including TIR (3.9-10.0 mmol/L) or pregnancy TIR (TIRp; 3.5-7.8 mmol/L)
Methodological detailssingle-centre, real-world data, paired t tests
- Single-centre
- Real-world data
- Paired t tests
Main finding
As reported in the abstract
HbA1c after HCL initiation (preconception and pregnancy) · 3-6 months (preconception); 3 months (pregnancy)
- Preconception: HbA1c reduced from 62.4 (14.0) to 54.2 (7.7) mmol/mol at 3-6 months (7.9 (1.3) to 7.1 (0.7) %)
- P < .0001
- Pregnancy: HbA1c reduced from 61.2 (14.6) to 48.1 (8.6) mmol/mol at 3 months (n = 36)
- P < .0001
Observational data: associations, not effects.
Further findings
- Postnatal continuous glucose monitoring (CGM) metrics · 1 month
- 70%
Time-in-range (TIR), preconception initiation · baseline, 1 week, 6 months
- TIR 49% at baseline to 65% at 1 week
- P < 0.001
- TIR 49% at baseline to 72% at 6 months
- P < 0.001
Time-below-range (TBR), preconception initiation · baseline, 1 week, 3 months
- TBR 3.2% at baseline to 2.1% at 1 week
- P = 0.006
- TBR 3.2% at baseline to 2.1% at 3 months
- P = 0.042
TIRp, pregnancy initiation · baseline to 1 week
- TIRp 37% baseline to 57% after 1 week
- P < 0.0001
Original publication
Effect of Automated Insulin Delivery Using Hybrid Closed Loops in the Preconception, Peripartum and Postnatal Periods for Women With Type 1 Diabetes. J Diabetes Sci Technol. Published 28 May 2025. doi:10.
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